An Interdisciplinary Team Caring for Children With Acute and Chronic Kidney Disease

Nephrology and Hypertension

Members of the Division of Nephrology and Hypertension provide compassionate, state-of-the-art care for patients with acute and chronic kidney disease. Our Division is at the forefront of research and discoveries that advance our understanding of kidney disease and its prevention, diagnosis, and treatment. We are dedicated to training physicians in the best practices in pediatric nephrology.
Clinical Services
The Division has four full-time and one part-time faculty members and provides comprehensive care for a wide range of kidney conditions. We have designated medical directors for our dialysis program and kidney transplantation program. The Division’s dedicated interdisciplinary team includes physicians, two nurses, a medical assistant, a dietitian, and a social worker who are all fully committed to caring for children with kidney disease and supporting them and their families through education and other resources.
Research
The Division currently receives NIH funding for basic science, clinical, and translational research. Our broad research areas encompass cell biology of kidney tubular response to ischemic injury or urinary tract obstruction, pathogenesis of acute kidney injury and chronic kidney disease, observational studies in glomerular disease, gene discoveries for congenital anomalies of the kidney and urology tract, and genetic studies for chronic kidney disease. We have ongoing and fruitful collaborations with precision medicine, adult nephrology, pathology, and neonatology. The knowledge we derive from this work will serve as the basis of future therapies for kidney disease.
Education
The Division is heavily invested in educating future generations of pediatricians and pediatric nephrologists. Since 2012, we have been one of the most popular subspecialties for medical student and resident rotations. Over the past eight years, two of our fellows were named Fellow of the Year, and one faculty member was voted Attending of the Year by pediatric residents at Columbia/NewYork-Presbyterian Morgan Stanley Children's Hospital. Through the Nephrology Fellowship program, we train pediatric nephrologists to achieve high competence in patient care, renal research, and education. The program emphasizes hands-on learning and didactic teaching, and through a rigorous curriculum, fellows learn to diagnose and treat children with a wide spectrum of acute and chronic kidney diseases. One of the current fellows received 2-year NIH funding for clinical research under the U2C/TL1 program.
Honors, Awards, Committees, Presentations/Invited Lectures
- Rushelle Byfield, MD, MSCE
- Poster Presentation, May 2024: Pediatric Academic Societies, "Home Blood Pressure Monitoring in Adolescents and Young Adults, NHANES 2009-2014"
- Oral Abstract, Sept 2024: American Heart Association Hypertension Sessions: "Ambulatory Blood Pressure Variability, Progression of Kidney Disease, and Cardiovascular Outcomes in the Chronic Renal Insufficiency Cohort"
- Invited Speaker, Sept 2024: Columbia Medicine CME 12th Annual Challenges In Hypertension: "Hypertension in Children & Adolescents" Nov 2024: American Heart Association Scientific Sessions: "Pecha Kucha: Future is Now - What is the Best Way to Reduce Blood Pressure Among Patients with Uncontrolled Hypertension?"
- Committees: Chair-Elect, American Heart Association, Council on Hypertension, Hypertension & Kidney in Cardiovascular Disease Committee
- Member, American Heart Association, Council On The Kidney In Cardiovascular Disease, Membership Committee
- Co-Chair, American Society of Pediatric Nephrology, Pathology Webinar Committee
- Hilda Fernandez, MD
- Invited Presentation, 06/2024 “Hereditary Kidney Disease” Open Medical Institute, Salzburg, Austria
- Invited Presentation, 06/2024 “Kidney Transplant Basics and Updates” Open Medical Institute, Salzburg, Austria
- Invited Presentation, 06/2024 “Renal Replacement Therapy: Hemodialysis and Peritoneal Dialysis” Open Medical Institute, Salzburg, Austria
- Invited Presentation, 06/2024 “Chronic Kidney Disease” Open Medical Institute, Salzburg, Austria
- Invited Presentation, 02/2024 “Transition of Care from Adolescence to Adulthood” Pediatric Grand Rounds, Staten Island University Hospital, Staten Island, NY
- University Presentation, 09/2024 “Transplant in ADPKD” Department of Medicine, Columbia University Irving Medical Center
- University Presentation, 03/2024 “Reducing Disparities for Kidney Transplantation in Hispanic/Latino Communities” Department of Surgery, Columbia University Medical Center
- University Presentation, 02/2024 “IgA Vasculitis” Department of Medicine, Columbia University Medical Center
- Continuing Medical Education, July 2024 Point of Care Ultrasound for Nephrologists - CME Course Co-Director, Department of Medicine, Columbia University Irving Medical Center, New York, NY
- Invited Poster Presentation, Gurusinghe S, Fernandez HE, Mahajan R, Lytrivi ID, Uy NS. “The Association of Proteinuria and Hypertension with Chronic Kidney Disease among Pediatric Heart Transplant Recipients” Poster Presentation at the Pediatric Academic Society Annual Meeting, Toronto, CA, May 2024
Major Grants
- Rushelle Byfield, MD
- Evaluating novel approaches for estimating awake and sleep blood pressure. BETTER BP R01. NIH. PI: Daichi Shimbo, MD.
- Incorporation of a Hypertension Working Group Into the Jackson Heart Study. JHS R01. NIH. PI: Daichi Shimbo, MD.
- Elliott Huang, MD
- New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR). NIH/NIDDK. PI: Jonathan M. Barasch, MD. Individual:
- Fangming Lin, MD, PhD
- New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR). NIH/NIDDK. Primary site: Albert Einstein College of Medicine. PI: Melamed, M.
- The Columbia PCC for CureGN: the Cure Glomerulonephropathy network. NIH/NIDDK. PI: Ali Gharavi.
- New York Consortium for Interdisciplinary Training in Kidney, Urological and Hematological Research (NYC Train KUHR). NIH/NIDDK. Primary Place of Performance: Albert Einstein College of Medicine. PD/PI: Melamed, M.
Selected Publications
- Antihypertensive medication nonadherence and target organ damage in children with chronic kidney disease. Byfield RL, Xiao R, Shimbo D, Kronish IM, Furth SL, Amaral S, Cohen JB. Pediatr Nephrol. 2024 Jan;39(1):221-231. doi: 10.1007/s00467-023-06059-w. Epub 2023 Jul 13.PMID: 37442816
- The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods. South AM, Giammattei VC, Bagley KW, Bakhoum CY, Beasley WH, Bily MB, Biswas S, Bridges AM, Byfield RL, Campbell JF, Chanchlani R, Chen A, D'Agostino McGowan L, Downs SM, Fergeson GM, Greenberg JH, Hill-Horowitz TA, Jensen ET, Kallash M, Kamel M, Kiessling SG, Kline DM, Laisure JR, Liu G, Londeree J, Lucas CB, Mannemuddhu SS, Mao KR, Misurac JM, Murphy MO, Nugent JT, Onugha EA, Pudupakkam A, Redmond KM, Riar S, Sethna CB, Siddiqui S, Thumann AL, Uss SR, Vincent CL, Viviano IV, Walsh MJ, White BD, Woroniecki RP, Wu M, Yamaguchi I, Yun E, Weaver DJ Jr. Am J Epidemiol. 2024 Jun 17:kwae116. doi: 10.1093/aje/kwae116. Online ahead of print. PMID: 38881045
- Home Blood Pressure Monitoring. Justin Liu, Jeffrey Brettler, Uriel A Ramirez, Sophie Walsh, Dona Sangapalaarachchi, Keisuke Narita, Rushelle L Byfield, Kristi Reynolds, Daichi Shimbo. American Journal of Hypertension, 2024;, hpae151, https://doi.org/10.1093/ajh/hpae151. In Press.
- Weiss R, Milo Rasouly H, Marasa M, Fernandez H, Lin F, Sabatello M. Nephrologists' Views on a Workflow for Returning Genetic Results to Research Participants. Kidney Int Rep. 2024 Sep 2;9(11):3278-3289. doi: 10.1016/j.ekir.2024.08.026. PMID: 39534211; PMCID: PMC11551134.
- Fernandez HE, Lipton M, Balderes O, Lin F, Marasa M, Milo Rasouly H, Sabatello M. Pediatric nephrologists' perspectives and clinical practices related to genetic testing and education. Pediatr Nephrol. 2024 Oct 9. doi: 10.1007/s00467-024-06539-7. Epub ahead of print. PMID: 39382664.
- Batal I, Watts AJB, Gibier JB, Hamroun A, Top I, Provot F, Keller K, Ye X, Fernandez HE, Leal R, Andeen NK, Crew RJ, Dube GK, Vasilescu ER, Ratner LE, Bowman N, Bomback AS, Sanna-Cherchi S, Kiryluk K, Weins A. Pre-transplant anti-nephrin antibodies are specific predictors of recurrent diffuse podocytopathy in the kidney allograft. Kidney Int. 2024 Oct;106(4):749-752. doi: 10.1016/j.kint.2024.07.022. Epub 2024 Aug 9. PMID: 39127225; PMCID: PMC11416305.
- Nuccitelli RA, Fernandez HE, Husain SA, Kudose S, Batal I, Sekulic M. Donor-derived membranous nephropathy in the allograft kidney: A rare but probably underestimated complication. Am J Transplant. 2024 Dec;24(12):2292-2298. doi: 10.1016/j.ajt.2024.08.002. Epub 2024 Aug 9. PMID: 39127179.
- Tarragón B, Peleg Y, Jagannathan G, Sekulic M, Chang JH, Cohen DJ, Crew RJ, Dube GK, Fernandez HE, Husain SA, Mohan S, Morris HK, Appel GB, Jadav P, Santoriello D, Kudose S, Stokes MB, Batal I, Bomback AS. C3 Glomerulopathy Recurs Early after Kidney Transplantation in Serial Biopsies Performed within the First 2 Years after Transplantation. Clin J Am Soc Nephrol. 2024 Aug 1;19(8):1005-1015. doi: 10.2215/CJN.0000000000000474. Epub 2024 Jun 7. PMID: 39116277; PMCID: PMC11321730.
- Lipman AR, Lytrivi ID, Fernandez HE, Lynch AM, Yu ME, Stevens JS, Mohan S, Husain SA. Acute Kidney Injury Requiring Dialysis After Pediatric Heart Transplant. Pediatr Transplant. 2024 Aug;28(5):e14829. doi: 10.1111/petr.14829. PMID: 39036942; PMCID: PMC11268797.
- Shen CL, Liebstein D, Fernandez H. Malnutrition and protein energy wasting are associated with severity and progression of pediatric chronic kidney disease. Pediatr Nephrol. 2024 Jan;39(1):243-250. doi: 10.1007/s00467-023-06078-7. Epub 2023 Jul 18. PMID: 37464056.
- Genome-wide studies define new genetic mechanisms of IgA vasculitis. Liu L, Zhu L, Monteiro-Martins S, Griffin A, Vlahos LJ, Fujita M, Berrouet C, Zanoni F, Marasa M, Zhang JY, Zhou XJ, Caliskan Y, Akchurin O, Al-Akash S, Jankauskiene A, Bodria M, Chishti A, Esposito C, Esposito V, Claes D, Tesar V, Davis TK, Samsonov D, Kaminska D, Hryszko T, Zaza G, Flynn JT, Iorember F, Lugani F, Rizk D, Julian BA, Hidalgo G, Kallash M, Biancone L, Amoroso A, Bono L, Mani LY, Vogt B, Lin F, Sreedharan R, Weng P, Ranch D, Xiao N, Quiroga A, Matar RB, Rheault MN, Wenderfer S, Selewski D, Lundberg S, Silva C, Mason S, Mahan JD, Vasylyeva TL, Mucha K, Foroncewicz B, Pączek L, Florczak M, Olszewska M, Gradzińska A, Szczepańska M, Machura E, Badeński A, Krakowczyk H, Sikora P, Kwella N, Miklaszewska M, Drożdż D, Zaniew M, Pawlaczyk K, SiniewiczLuzeńczyk K, Bomback AS, Appel GB, Izzi C, Scolari F, Materna-Kiryluk A, Mizerska-Wasiak M, Berthelot L, Pillebout E, Monteiro RC, Novak J, Green TJ, Smoyer WE, Hastings MC, Wyatt RJ, Nelson R, Martin J, González-Gay MA, De Jager PL, Köttgen A, Califano A, Gharavi AG, Zhang H, Kiryluk K. medRxiv [Preprint]. 2024 Oct 11:2024.10.10.24315041. doi: 10.1101/2024.10.10.24315041. PMID: 39417133 Free PMC article. Preprint.
- Pediatric nephrologists' perspectives and clinical practices related to genetic testing and education. Fernandez HE, Lipton M, Balderes O, Lin F, Marasa M, Milo Rasouly H, Sabatello M. Pediatr Nephrol. 2024 Oct 9. doi: 10.1007/s00467-024-06539-7. Online ahead of print. PMID: 39382664
- Nephrologists' Views on a Workflow for Returning Genetic Results to Research Participants. Weiss R, Milo Rasouly H, Marasa M, Fernandez H, Lin F, Sabatello M. Kidney Int Rep. 2024 Sep 2;9(11):3278-3289. doi: 10.1016/j.ekir.2024.08.026. eCollection 2024 Nov. PMID: 39534211 Free PMC article.